CONICS (COpy-Number analysis In single-Cell RNA-Sequencing) is a tool to analyze copy-number variation (CNV) in single-cell RNA-seq data. CONICS quantifies CNV, maps gene expressions to tumor clones, and phylogenies.
RNA-seq; DNA structural variation; Genetic variation
Muller S, Cho A, Liu SJ, Lim DA, Diaz A "CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones." Bioinformatics. 2018 Sep 15;34(18):3217-3219. https://doi.org/10.1093/bioinformatics/bty316
PMID: 29897414
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