VDJPuzzle is a tool to reconstruct full-length B-cell receptors from single-cell RNA-seq data sets. The VDJPuzzle algorithm can reconstruct both heavy and light chains, and detect mutations in the V(D)J region.
Cell biology; RNA-seq; Immunoproteins, genes and antigens
Rizzetto S, Koppstein DNP, Samir J, Singh M, Reed JH, Cai CH, Lloyd AR, Eltahla AA, Goodnow CC, Luciani F "B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle." Bioinformatics. 2018 Aug 15;34(16):2846-2847. https://doi.org/10.1093/bioinformatics/bty203
PMID: 29659703
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