4DGenome

4DGenome provides a curated repository of chromatin interaction data across Homo sapiens, Mus musculus, Drosophila melanogaster, Plasmodium falciparum, and Saccharomyces cerevisiae to support analysis of three-dimensional genome organization and gene regulation.

Key Features:

• Extensive Data Coverage: Contains chromatin interaction data from low- and high-throughput assays including 3C, 4C-Seq, 5C, Hi-C, ChIA-PET, and Capture-C.
• Integration of Predictive Models: Includes predicted chromatin interactions generated by a computational method reported to have high accuracy.
• Comprehensive Record Keeping: Holds approximately 8 million records spanning over 102 distinct cell or tissue types across the five organisms and stored using a standardized file format.
• Confidence Scoring System: Assigns confidence scores to a substantial portion of interactions to indicate the reliability of recorded interactions.

Scientific Applications:

• Chromatin architecture analysis: Enables study of three-dimensional genome organization and long-range chromatin interactions.
• Gene regulation research: Supports investigation of regulatory interactions that influence gene expression.
• Epigenetics and developmental biology: Facilitates analyses of chromatin conformation differences across cell types and developmental contexts.
• Disease genomics: Provides interaction data applicable to studying chromatin alterations in disease contexts.

Methodology:

Data compilation is based on rigorous literature curation.