4D Nucleome Data Portal

4D Nucleome Data Portal provides curated genomic and microscopy datasets and visualization resources for analyzing the three-dimensional and temporal organization of chromosomes within the nucleus.

Key Features:

• Extensive Dataset Repository: Contains over 1,800 experiment sets and 34,000 files from the 4DN Network and external sources, including Hi-C, other chromosome conformation capture assays, sequencing, and microscopy-based assays.
• Uniform Processing and Quality Control: Submitted datasets undergo uniform processing and rigorous quality control across laboratories to ensure consistency and reliability.
• Interactive Visualization (HiGlass): Integrates HiGlass to provide interactive 1D and 2D genome displays that enable creation and comparison of multiple datasets.

Scientific Applications:

• Chromosome contact map analysis: Supports analysis of Hi-C and other conformation capture data to study contact maps and chromosomal interactions.
• Nuclear architecture and genome organization: Enables investigation of three-dimensional genome organization and its dynamics using sequencing and microscopy datasets.
• Disease-related genome organization studies: Facilitates studies linking chromosomal organization to cellular function and disease states.

Methodology:

The portal collects and curates experimental datasets, applies uniform processing and rigorous quality control, and integrates data with HiGlass for interactive 1D and 2D visualization.