AcetoBase

AcetoBase compiles and analyzes formyltetrahydrofolate synthetase (FTHFS) gene sequences to support identification and characterization of acetogenic bacteria.

Key Features:

• FTHFS Sequence Repository: Collects formyltetrahydrofolate synthetase (FTHFS) sequences at nucleotide and protein levels for acetogenic bacteria.
• Custom BLAST Database: Enables homology searches using a customized BLAST database to compare FTHFS sequences.
• Sequence Submission and Accession Assignment: Allows researchers to submit FTHFS sequence data and obtain accession numbers for database integration.
• Metadata Integration: Associates sequence entries with metadata including genome content and information related to the Wood–Ljungdahl pathway.

Scientific Applications:

• Acetogenic Bacteria Identification: Identifies acetogenic microorganisms using FTHFS gene sequences as molecular markers.
• Microbial Taxonomy Studies: Supports taxonomic classification of physiologically and genetically diverse acetogens.
• Microbial Ecology and Carbon Cycling Research: Investigates the ecological roles of acetogenic bacteria in environmental carbon cycling.
• Biotechnology Research: Provides sequence resources for studying acetogen metabolic pathways relevant to biotechnological applications.

Methodology:

AcetoBase compiles nucleotide and protein sequences of the formyltetrahydrofolate synthetase (FTHFS) gene, integrates associated genomic and Wood–Ljungdahl pathway metadata, and enables sequence comparison through a customized BLAST database to identify acetogenic bacteria.