AmtDB

AmtDB provides a curated collection of ancient mitochondrial DNA (mtDNA) sequences from anatomically modern Homo sapiens and associated metadata to support population genetic and paleogenomic analyses.

Key Features:

• Dataset size and scope: Over 1107 ancient mtDNA sequences from anatomically modern Homo sapiens samples spanning the late Paleolithic to Iron Age periods in Euroasian regions.
• Sample metadata: Each entry includes sample IDs, radiocarbon dating, geographic coordinates, archaeological site details, cultural affiliations, and mtDNA haplogroups.
• Sequence formats: Sequences are provided in FASTA format for computational compatibility.
• Metadata formats: Metadata is available as a tab-delimited text file for integration with analysis tools.
• Geospatial visualization: Map-based visualization enables analysis of sample geographic distribution, spatial patterns, and temporal demographic shifts.

Scientific Applications:

• Population genetics: Enables analysis of mtDNA variability at the population level for studies of genetic structure and migration.
• Lineage tracing: Supports tracing of maternal lineages using mtDNA haplogroups and sequence variation.
• Evolutionary pattern analysis: Facilitates investigation of evolutionary dynamics across the late Paleolithic to Iron Age time span.
• Cultural affiliation studies: Allows investigation of associations between genetic markers and archaeological cultural affiliations using data generated by high-throughput sequencing and capture enrichment methods.

Methodology:

Data undergoes curation with validation of geographic location, dating, and archaeological context, and descriptors are documented for each entry.