Aneuvis

Aneuvis visualizes and quantifies numerical chromosomal variation from molecular cytogenetic or processed single-cell whole-genome sequencing data.

Key Features:

• Input format: Accepts data formatted as a cell-by-chromosome matrix derived from molecular cytogenetic assays or processed single-cell whole-genome sequencing.
• Automated visualization and statistics: Generates comprehensive visual representations and summary statistics that describe numerical chromosomal variability.
• Comparative analysis: Performs comparisons between experimental treatment groups to detect significant differences in numerical chromosomal variation.
• Scalable processing: Designed to process large single-cell datasets for high-throughput analyses.

Scientific Applications:

• Characterization of malignancy: Quantifies numerical chromosomal variation characteristic of malignant cell populations.
• Assessment of chromosomal instability: Supports identification of factors and conditions that contribute to chromosomal instability.
• Treatment effect analysis: Enables comparison of experimental treatments to evaluate their impact on numerical chromosomal variation, aiding investigation of potential therapeutic effects.

Methodology:

Processes cell-by-chromosome matrices from molecular cytogenetic or processed single-cell whole-genome sequencing data to compute summary statistics and generate visual representations.