BBCancer

BBCancer provides a comprehensive blood-based RNA expression atlas to support discovery of cancer biomarkers from high-throughput gene expression data of patient blood samples.

Key Features:

• Comprehensive RNA expression atlas: Expression profiles for six RNA types—mRNAs, long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs), tRNA-derived fragments (tRF-RNAs), and Piwi-interacting RNAs (piRNAs)—are included.
• Diverse blood sample types: Data derive from plasma, circulating tumor cells (CTCs), and extracellular vesicles (EVs).
• Extensive dataset: The resource contains expression data for 5040 normal and tumor blood samples spanning 15 cancer types.

Scientific Applications:

• Biomarker discovery: Identify novel blood-based biomarkers for non-invasive early cancer screening through analysis of RNA expression signatures.
• Comparative molecular analysis: Compare normal and tumor blood sample expression profiles to investigate molecular differences across cancers.
• Therapeutic target exploration: Analyze differential expression patterns to prioritize potential therapeutic targets.

Methodology:

High-throughput gene expression profiling was used to measure expression levels across thousands of genes in blood-derived samples.