BiGG Models

BiGG Models hosts a centralized knowledgebase of high-quality genome-scale metabolic network reconstructions to provide standardized, validated genome-scale models linked to genome annotations and external databases for comparative and systems-level metabolic analysis across phylogenetic diversity.

Key Features:

• Repository content: Contains gold-standard and multi-strain genome-scale metabolic network reconstructions.
• Phylogenetic coverage: Includes models spanning the phylogenetic tree and has been expanded with 31 new models.
• Genome annotation linking: Connects each model to relevant genome annotations and external databases.
• Standardization: Ensures standardized representation of reactions and metabolites across models.
• Multi-strain model support: Hosts multi-strain models intended for comparative analyses of related strains.
• Quality validation: Employs Memote, a community-developed validator for genome-scale models.

Scientific Applications:

• Comparative strain analysis: Enables comparison of related strains to investigate genetic and metabolic variation.
• Metabolic network reconstruction and analysis: Supports reconstruction and analysis of genome-scale metabolic networks.
• Systems biology and bioinformatics: Provides standardized, high-quality models for systems-level and bioinformatics investigations of metabolism.

Methodology:

Models are linked to genome annotations and external databases, reactions and metabolites are standardized across models, and model quality is assessed using Memote.