BiomeNet

BiomeNet constructs and analyzes functional interaction networks across sequenced genomes to enable functional annotation and prediction of gene functions, supporting projects such as the Earth BioGenome Project.

Key Features:

• Extensive Network Database: 95 scored networks comprising over 8 million co-functional links spanning 5 animal, 6 plant, 5 bacterial, and 2 fungal species.
• Orthologous Protein Link Transfer: Transfers co-functional links between orthologous proteins from source networks to target species, enabling automatic construction of gene networks with quality comparable to existing databases.
• Predictive and Analytical Capabilities: Enables assembly of first-in-species gene networks predictive of diverse biological processes, extraction of function-specific subnetworks, and network-based gene prioritization.
• Facilitation of Functional Annotation: Uses network biology to place gene function predictions in the context of collaborative gene interactions for genome annotation.

Scientific Applications:

• Functional annotation: Supports functional annotation and molecular network analyses for newly sequenced genomes to elucidate gene functions and pathways.
• Biodiversity genomics: Supports large-scale efforts such as the Earth BioGenome Project by transferring functional links across taxa.
• Research applications: Enables predictive network analyses relevant to genetics, evolutionary biology, and ecology.

Methodology:

Transferring co-functional links from 95 scored, validated source networks between orthologous proteins to construct target-species gene networks.