CASet

CASet computes a distance measure between tumor evolutionary trees to quantify relationships between tree topology and mutation inheritance patterns.

Key Features:

• Novel distance measures: Introduces the Common Ancestor Set (CASet) distance to quantify differences between tumor evolutionary trees.
• Subclonal mutation inheritance patterns: Accounts for subclonal mutation inheritance patterns characteristic of tumor evolution when comparing trees.
• Enhanced resolution: Provides finer differentiation between evolutionary trees than existing measures.

Scientific Applications:

• Benchmarking tree inference methods: Enables quantitative comparison of inferred tumor evolutionary trees for benchmarking purposes.
• Evaluating inheritance patterns across patients: Assesses common mutation inheritance patterns across different patient datasets.
• Comparative studies on tumor evolution: Supports comparison of tumor evolutionary histories using simulated and real-world datasets.

Methodology:

Application of two distance measures—Common Ancestor Set (CASet) and Distinctly Inherited Set Comparison (DISC)—with evaluation on multiple simulated datasets and two breast cancer datasets.