Clinical Drug Experience Knowledgebase (CDEK)

Clinical Drug Experience Knowledgebase (CDEK) provides a curated database of active pharmaceutical ingredients (APIs), clinical trials, and organizations linked to clinical testing to support drug development research.

Key Features:

• Curated clinical evidence: Aggregates APIs with documented evidence of clinical testing and links them to associated clinical trials and organizations.
• Data provenance: Sources include ClinicalTrials.gov and cross-references with other prominent drug databases to support data integrity.
• Name disambiguation: Performs disambiguation of intervention and organization names extracted from ClinicalTrials.gov.
• Content scope: Contains 22,292 active pharmaceutical ingredient entries, 127,223 clinical trial entries, and 24,728 organization entries.
• Unique API coverage: Approximately 43% of APIs in CDEK are reported as unique to this database and sourced exclusively from ClinicalTrials.gov.
• Queryable data model: Supports construction of custom queries by selecting table columns and applying filtration predicates.

Scientific Applications:

• Drug Discovery: Enables identification and exploration of potential drug candidates by providing clinical-evidence-linked API entries.
• Repurposing Opportunities: Facilitates analysis of existing drugs and their clinical histories to identify novel therapeutic uses.
• Chemo- and Bioinformatics: Supports analysis of chemical properties and biological interactions associated with APIs using linked clinical data.
• Clinical and Translational Research: Connects clinical trial records to pharmaceutical ingredients to aid translation of research findings into clinical contexts.
• Regulatory Sciences: Provides comprehensive clinical and API data to assist regulatory evaluation of drug safety and efficacy.

Methodology:

Curates records by disambiguating intervention and organization names from ClinicalTrials.gov and cross-referencing these entries with other drug databases; supports query construction via selection of table columns and filtration predicates.