CHOmine

CHOmine provides an integrated database of genetic, proteomic, and phenotypic data for Cricetulus griseus and Chinese hamster ovary (CHO) cells to support research in genetics, molecular biology, and bioprocessing.

Key Features:

• Complex Data Integration: Leverages the InterMine data warehouse framework to integrate heterogeneous genetic, proteomic, and phenotypic datasets for Cricetulus griseus and CHO cells.
• Customizable Query Facility: Offers a flexible query builder that supports detailed searches across integrated datasets, including genomic region searches.
• Extensible Data Model: Employs an extensible schema that allows addition of new data types as they become available.
• Statistical Analysis Tools: Includes a library of widgets for performing statistical analyses on integrated datasets.
• Export Capabilities: Enables export of query results in multiple commonly used file formats.
• Extensible Framework: Provides mechanisms for developers to add new tools and functionalities to the platform.
• Web Services and Client Libraries: Exposes web services and provides client libraries in five commonly used programming languages.

Scientific Applications:

• Bioprocessing and protein production: Supports research on CHO-based production of therapeutic proteins and vaccines.
• Genetic engineering and cell line development: Facilitates studies for engineering, developing, and optimizing CHO cell lines and protein expression.
• Comparative and evolutionary genomics: Enables comparative analyses between Cricetulus griseus and CHO cells to inform evolutionary and species-comparison studies.
• Functional genomics and molecular biology: Supports investigations into gene function, molecular mechanisms, and related biological processes.

Methodology:

Built on the InterMine framework, CHOmine integrates heterogeneous biological datasets, provides a customizable query builder with genomic region search support, implements a widget-based statistical analysis library, supports export in multiple formats, and exposes web services with client libraries in five programming languages.