CaSiAn

CaSiAn analyzes calcium (Ca2+) signaling time-series to quantify individual spike properties and time-course statistics for studying cellular Ca2+ dynamics.

Key Features:

• Quantitative Analysis: Quantifies individual spike properties and time-course statistics from Ca2+ signals.
• Semi-automated Processing: Provides semi-automated processing with adjustable peak-detection parameters and the ability to revise statistical measures.
• Peak Detection: Detects spikes in Ca2+ time courses and reports peak-related metrics for downstream analysis.
• Data Export: Exports quantified signal properties to Excel and plain text file formats.

Scientific Applications:

• Cell Type-Specific Analysis: Enables comparison of Ca2+ spike characteristics across different cell types.
• Pathway-Specific Studies: Supports analysis of pathway-specific Ca2+ signaling features to investigate regulatory mechanisms.
• Comparative Studies: Facilitates comparative analyses between experimental conditions or treatments to identify signaling alterations.

Methodology:

Semi-automated peak detection and quantification of individual spike properties and time-course statistics with adjustable peak-detection and statistical parameters; implemented in Java.