CardioFAN

CardioFAN models pulsatile fluid-structure interactions in viscous hyperelastic cardiovascular networks to predict pulse transit time (PTT), pulse wave velocity, vessel compliance, and pressure/flow waveforms for noninvasive hemodynamic assessment.

Key Features:

• Mathematical and Numerical Tools: Employs advanced mathematical models and numerical methods to predict PTT, local pulse wave velocity, vessel compliance, and pressure/flow waveforms in viscous hyperelastic cardiovascular networks.
• Pulsatile Fluid-Structure Interaction Framework: Implements a one-dimensional framework for pulsatile fluid-structure interaction in hyperelastic arteries and solves the associated hyperbolic equations using a high-resolution total variation diminishing Lax-Wendroff method.
• Validation and Accuracy: Algorithms validated against numerical, in vitro, and in vivo data for networks of main human arteries comprising 55, 37, and 26 segments.
• Hyperelastic Nonlinear Wave Analysis: Incorporates hyperelastic nonlinear wave dynamics between arterial sections to improve PTT prediction and refine arterial compliance assignments, including a 26-segment model of the human aorta and supra-aortic branches.
• Improved Predictive Performance: Demonstrates a 1.5% overall enhancement in waveform predictions and maintains average relative errors of 5.5% for flow, luminal area, and pressure waveforms relative to prior in vivo measurements.
• Patient-Specific Calibration: Supports calibration of arterial compliance and hemodynamic parameters for arbitrary patient-specific vascular networks.

Scientific Applications:

• Noninvasive Hemodynamic Assessment: Enables noninvasive prediction and analysis of PTT, pulse wave velocity, and pressure/flow waveforms for hemodynamic evaluation.
• Clinical Diagnostics: Supports extraction of patient-specific biomarkers for cardiovascular diagnostics using modeled hemodynamic metrics.
• Personalized Medicine: Facilitates patient-specific vascular network calibration and personalized arterial compliance assignment for individualized modeling.
• Therapeutic Development: Provides validated waveform and compliance predictions useful for developing and assessing targeted cardiovascular interventions.

Methodology:

Uses a one-dimensional pulsatile fluid-structure interaction framework solving hyperbolic equations with a high-resolution total variation diminishing Lax-Wendroff method; incorporates hyperelastic nonlinear wave dynamics between arterial sections and validation against numerical, in vitro, and in vivo data for 55-, 37-, and 26-segment human arterial networks.