ClustalW2 Phylogeny API EBI

ClustalW2 Phylogeny API EBI generates phylogenetic trees from multiple sequence alignments to infer evolutionary relationships using Neighbor-joining or UPGMA methods.

Key Features:

• Rewritten algorithms: Core ClustalW2 algorithms have been rewritten in C++ to improve performance and maintainability.
• Multiple sequence alignment: Performs multiple sequence alignment using ClustalW2 to identify homologous positions across input sequences.
• Phylogenetic tree construction: Constructs phylogenetic trees using the Neighbor-joining and UPGMA algorithms.
• Scalability: Uses Neighbor-joining and UPGMA methods selected for their capacity to handle large datasets efficiently.

Scientific Applications:

• Evolutionary Biology: Inferring evolutionary relationships among species or genes from sequence data.
• Genomics: Analyzing genetic variation and identifying conserved regions across multiple sequences.
• Protein Structure Prediction: Inferring structural similarities among proteins based on sequence alignments.

Methodology:

Performs a multiple sequence alignment using ClustalW2 and then constructs phylogenetic trees using either the Neighbor-joining or UPGMA methods.