CodAn

CodAn annotates coding sequences (CDS) and untranslated regions (UTRs) in eukaryotic transcripts to improve the accuracy of transcriptome annotation and protein-coding gene prediction.

Key Features:

• Enhanced Prediction Accuracy: Improves CDS prediction accuracy in strand-blind and partial sequences, reducing errors in downstream protein inference.
• Strand-specific Full-CDS Prediction: Achieves high-accuracy full-CDS prediction in strand-specific sequences, matching or surpassing current gold-standard methods.
• Stop Codon Position Prediction: Accurately determines stop codon positions within strand-specific sequences.
• CDS and UTR Characterization: Annotates both coding sequences and untranslated regions in eukaryotic transcripts.
• Protein Prediction Support: Enhances the reliability of protein-coding gene prediction by providing improved CDS annotations.

Scientific Applications:

• Transcriptome Annotation: Provides reliable CDS and UTR annotations for constructing accurate genomic and transcriptomic databases.
• Protein Prediction: Improves identification and prediction of protein-coding genes by reducing propagation of erroneous CDS calls.

Methodology:

Uses a novel computational approach leveraging advanced algorithms to improve CDS and UTR predictions in strand-blind and partial eukaryotic transcript sequences.