ColonySizeDistributions

ColonySizeDistributions quantifies metastatic colony growth dynamics and size distributions from imaging data of disseminated cancer cells in vitro and in vivo.

Key Features:

• Image-Based Colony Quantification: Analyzes tissue section images to measure the size distribution and spatial localization of metastatic lesions.
• Metastatic Lesion Detection: Identifies multiple subpopulations of disseminated cells within metastatic sites.
• High-Throughput Imaging Analysis: Supports analysis of live or fixed cell imaging datasets for high-throughput quantification of colony growth.
• Colony Size Distribution Measurement: Generates quantitative distributions of metastatic colony sizes for downstream computational modeling.

Scientific Applications:

• Metastasis Research: Quantifies growth patterns of metastatic colonies in experimental cancer models.
• Clonal Fitness and Evolution Analysis: Evaluates proliferation dynamics of disseminated cancer cell subpopulations.
• Cancer Systems Modeling: Provides quantitative datasets for computational models of metastatic progression.

Methodology:

ColonySizeDistributions processes microscopy images of tissue sections using MATLAB scripts to detect metastatic colonies and compute quantitative size distributions and spatial localization of lesions.