DIMERBOW

DIMERBOW catalogs and visualizes potential dimeric interfaces of G protein-coupled receptors (GPCRs) identified from crystallographic contacts in Protein Data Bank (PDB) structures to support structural modeling of GPCR oligomers.

Key Features:

• PDB-derived dataset: Aggregates GPCR structures from the Protein Data Bank (PDB) as the source of structural data.
• Crystallographic interface annotation: Identifies and records crystallographic interfaces in solved structures that are indicative of potential physiological GPCR interactions.
• Comprehensive repertoire of dimers: Enumerates possible GPCR dimer pairs and quaternary arrangements derivable from available solved structures.
• Structural templates for modeling: Provides structural examples suitable for use as templates when modeling GPCR homomers and higher-order oligomers.

Scientific Applications:

• GPCR oligomer modeling: Supports selection of structural templates for homomer and heteromer modeling of GPCRs.
• Quaternary structure analysis: Aids investigation of GPCR quaternary arrangements and interface composition derived from crystallographic contacts.
• Pharmacological hypothesis generation: Informs studies on how GPCR dimerization and oligomerization may influence receptor function and drug targeting.

Methodology:

Extraction and curation of crystallographic interfaces from GPCR entries in the Protein Data Bank (PDB) to identify and catalog potential dimeric contacts observable in solved structures.