EuRBPDB

EuRBPDB provides a curated compendium of eukaryotic RNA binding proteins (RBPs) and their annotations to support comparative genomics and cancer-related analyses.

Key Features:

• Comprehensive RBP collection: Contains 311,571 RBPs identified from 162 eukaryotic species, including humans, mice, flies, worms, and yeast, encompassing canonical RBPs with known RNA binding domains (RBDs) and 3,651 non-canonical RBPs lacking identifiable RBDs.
• Ortholog grouping: Organizes proteins into 6,368 ortholog groups to facilitate comparative studies across species.
• Annotation integration: Provides detailed annotations for each entry sourced from various public databases covering basic characteristics and functional roles.
• Proteomic and computational identification: Integrates large-scale RNA binding proteomic data with computational analyses to systematically identify RBPs.
• Cancer-related data integration: Incorporates published literature, protein-protein interaction networks (PPI-networks), and extensive omics datasets to evaluate the clinical relevance of RBPs in multiple cancer types.

Scientific Applications:

• Comparative genomics: Enables cross-species comparison of RBPs via ortholog groups and the multi-species dataset.
• RNA biology and functional analysis: Supports study of RBP basic characteristics, functional roles, and distinction between canonical and non-canonical RBPs.
• Cancer research: Facilitates systematic investigation of RBPs' clinical relevance in various cancer types using literature, PPI-networks, and omics datasets.

Methodology:

Integration of large-scale RNA binding proteomic data with computational analyses to identify RBPs; grouping proteins into 6,368 ortholog groups; incorporation of published literature, protein-protein interaction networks (PPI-networks), and extensive omics datasets for cancer relevance.