FAConstructor

FAConstructor generates synthetic nerve fiber models for use in 3D polarized light imaging (3D-PLI) simulations.

Key Features:

• Interactive modeling: defines nerve fiber pathways using interpolation methods or parametric functions.
• Model generation and modification: creates and modifies synthetic nerve fiber configurations for simulation input.
• Efficiency and performance: maintains over 30 frames per second for fiber models with fewer than 1.6 million data points.
• 3D-PLI simulation validation: produces synthetic models validated with the Fiber Cup phantom that reproduce known effects from 3D-PLI measurements.

Scientific Applications:

• High-resolution postmortem fiber orientation reconstruction: supports reconstruction of nerve fiber orientations in postmortem brains at ultra-high resolution.
• 3D-PLI numerical simulation studies: provides input models for numerical simulations to study the physical principles of 3D-PLI.
• Brain architecture and connectivity analysis: enables testing and development of methods for analyzing brain architecture and connectivity.

Methodology:

Defines nerve fiber pathways using interpolation methods or parametric functions and supports numerical simulations; validation was performed using the Fiber Cup phantom.