Funmap2

Funmap2 performs QTL mapping of longitudinal phenotypes using a functional mapping framework to characterize temporal genetic effects.

Key Features:

• Integration of Longitudinal Data Analysis: Incorporates longitudinal phenotypic data into QTL mapping to analyze trait dynamics over time.
• Functional Mapping Framework: Implements a functional mapping framework that integrates prior biological knowledge into statistical models.
• Automatic Model Selection: Automatically selects longitudinal curves and covariance matrices using information criteria.
• Comprehensive Genetic Effect Modeling: Describes genetic effects through longitudinal curves to capture temporal dynamics of trait expression.

Scientific Applications:

• QTL mapping of complex traits: Map QTLs that influence traits with complex genetic architectures across time.
• Developmental genetics: Investigate how genetic factors contribute to the development and progression of phenotypic traits.
• Temporal gene expression analysis: Explore temporal dynamics of gene expression and its impact on phenotype.

Methodology:

Incorporates longitudinal phenotypic data; specifies models with a functional mapping framework including genetic effects and covariance structures over time; uses information criteria to select longitudinal curves and covariance matrices; performs statistical analyses to identify QTLs considering genetic and temporal factors.