GENOMICUS

GENOMICUS visualizes conservation and synteny of genomic blocks across eukaryotic genomes to support comparative and evolutionary genomics analyses.

Key Features:

• Graphical conserved-block representation: Graphical representation of conserved genomic blocks among multiple genomes with support for both local gene-centered views and genome-wide karyotype comparisons.
• Extensive dataset: Includes 1,029 extant genomes and 621 ancestral reconstructions sourced from Ensembl and Ensembl Genomes.
• Ancestral genome reconstruction: Incorporates reconstructed ancestral gene organizations to aid interpretation of evolutionary events.
• Unlimited-genome comparison: Capability to represent and compare an unlimited number of genomes simultaneously.
• Taxon-specific instances: Four specialized instances tailored to specific taxonomic groups.
• Release synchronization: Synchronization across over 60 Ensembl releases to maintain updated gene annotations.
• Synteny browsing and queries: Visualization and query functionalities enabling synteny browsing across broad phylogenetic ranges.

Scientific Applications:

• Synteny analysis: Comparative analysis of synteny and conserved gene order across eukaryotic species.
• Gene-organization evolution: Investigation of the evolution of gene organization and large-scale genome rearrangements.
• Ancestral-state interpretation: Interpretation of evolutionary events using ancestral gene organization reconstructions.
• Local gene-centered studies: Local comparative analyses around specific genes to study conservation and context.
• Broad phylogenomic comparisons: Phylogenomic studies across diverse eukaryotic lineages enabled by wide taxonomic coverage.

Methodology:

Data are sourced from Ensembl and Ensembl Genomes and synchronized across Ensembl releases; conserved genomic blocks are represented graphically, karyotype comparisons are performed, and ancestral gene organizations are incorporated as reconstructions.