GreatSPN

GreatSPN is an open-source software suite for modeling and analyzing complex systems using the Petri Net (PN) formalism. It provides a compact graphical description of the system and automatically derives a set of Ordinary Differential Equations (ODEs) that encode the system dynamics. GreatSPN also incorporates the Latin Hypercube Sampling with a Partial Rank Correlation Coefficient (PRCC) index for calibrating ODE parameters to reproduce real-world behaviors in healthy subjects and those with specific conditions. The tool enables researchers to construct and study models of complex systems, such as the progression of Relapsing-Remitting Multiple Sclerosis (RRMS) under different scenarios, including the effects of drug administration and the disease's behavior during pregnancy.