H3ABioNet

H3ABioNet develops portable, reproducible genomic analysis pipelines and workflows to support genomic research and harmonized analyses within H3Africa (Human Health and Heredity in Africa Consortium) projects.

Key Features:

• Portable and Reproducible Pipelines: Development of genomic analysis pipelines that are portable across computing environments and reproducible for consistent results.
• Adaptation to Heterogeneous Computing Environments: Creation of workflows that operate across diverse computational infrastructures, including cloud computing platforms.
• Technical Expertise Development: Emphasis on building capacity in workflow languages and containerization technologies among researchers.
• Standard Operating Procedures (SOPs): Use of established SOPs for common genomic analyses to guide pipeline development and ensure methodological consistency.
• Hackathon Initiatives: Organization of events such as the Cloud Computing and Reproducible Workflows Hackathon (2016) to translate SOPs into practical analysis pipelines and develop participant skills.

Scientific Applications:

• H3Africa Genomic Research: Support for genomic research under the H3Africa consortium focused on human health and heredity across African populations.
• Sequencing and Data Interpretation: Enabling reproducible workflows for genomic sequencing analyses and subsequent complex data interpretation.

Methodology:

Translating established SOPs into executable analysis pipelines; creating workflows based on SOPs that are adaptable to diverse computational environments; encapsulating workflows using containerization technologies to ensure consistent execution across systems.