HMP2

HMP2 (Integrative Human Microbiome Project 2) integrates longitudinal multi-omics and clinical data to characterize host–microbiome interactions in inflammatory bowel diseases, specifically Crohn's disease and ulcerative colitis.

Key Features:

• Longitudinal Data Collection: Longitudinal study of 132 subjects over one year with up to 24 time points per individual, generating 2,965 stool, biopsy, and blood specimens.
• Comprehensive Molecular Profiling: Generates microbial transcriptional activity profiles, metabolite pools including acylcarnitines, bile acids, and short-chain fatty acids, and host serum antibody levels.
• Functional Dysbiosis Analysis: Identifies shifts such as increases in facultative anaerobes at the expense of obligate anaerobes and disruptions in microbial transcription among clostridia.
• Temporal Variability Assessment: Assesses taxonomic, functional, and biochemical shifts during periods of disease activity over time.
• Integrative Analysis Capabilities: Integrates microbial, biochemical, and host data to identify central factors contributing to dysregulation in IBD.
• Data Deposition: Study results and datasets are deposited in the Inflammatory Bowel Disease Multi'omics Database (IBDMDB).

Scientific Applications:

• Research on Inflammatory Bowel Diseases: Supports studies of Crohn's disease and ulcerative colitis using longitudinal multi-omics and clinical measurements.
• Microbiome Studies: Enables investigation of gut microbial community composition, transcriptional activity, and functional dysbiosis.
• Bioinformatics and Data Analysis: Provides integrated multi-omics datasets suitable for computational analyses of host–microbe interactions and disease-associated biomarkers.

Methodology:

Integration of longitudinal molecular profiles with clinical observations using diverse omics technologies to capture taxonomic, transcriptional, metabolite, and serological measurements.