Human Proteoform Atlas

Human Proteoform Atlas catalogs experimentally verified human proteoforms and assigns persistent FAIR (Findable, Accessible, Interoperable, Reusable) identifiers to enable proteoform tracking and ontology-based classification.

Key Features:

• Catalog of experimentally verified proteoforms: Maintains a registry of experimentally validated human proteoforms characterized by unique combinations of post-translational modifications (PTMs), alternative splicing, and genetic variations.
• FAIR persistent identifiers: Applies FAIR principles to assign persistent identifiers to proteoforms for unambiguous referencing and tracking.
• Redundancy calling and tracking: Supports redundancy calling and tracking of proteoforms across multiple studies to enable consistent identification.
• Open ontology-based classification: Organizes proteoforms using open ontologies to provide a flexible classification scheme.
• Public registry: Houses experimentally verified proteoforms in a public registry to record curated entries.
• Provenance from CTDP Proteoform Atlas: Represents an evolution of the Consortium of Top-Down Proteomics (CTDP) Proteoform Atlas.

Scientific Applications:

• Proteoform tracking: Enables tracking of specific proteoforms and their redundancy across studies to support reproducible proteoform identification.
• Ontology-driven annotation: Facilitates ontology-based classification and interoperability for integrative proteoform analyses.
• Functional assignment support: Provides a foundation for organizing and assigning functions to proteoforms, their PTMs, and associated complexes to advance protein biology and disease research.

Methodology:

Assigns persistent identifiers according to FAIR principles, uses open ontologies for proteoform classification, and maintains a public registry to support redundancy calling and tracking of experimentally verified proteoforms.