HVint2.0

HVint2.0 integrates experimentally supported and computationally predicted protein-protein interactions (PPIs) across representative species—herpes simplex virus 1, human cytomegalovirus, and Epstein-Barr virus—to define the conserved central intraviral protein interactome of the Herpesviridae family.

Key Features:

• Integrated PPI dataset: Aggregates experimentally supported and computationally predicted protein-protein interactions (PPIs).
• Representative species coverage: Includes representative species from the three Herpesviridae subfamilies: herpes simplex virus 1, human cytomegalovirus, and Epstein-Barr virus.
• Comparative evolutionary analysis: Performs comparative analysis across species to identify family-wise conserved interactions.
• Central intraviral protein interactome: Defines a "central" intraviral protein interactome composed of conserved interactions and protein complexes essential for the productive viral lifecycle.
• Minimal infectious interactome: Encapsulates a minimal infectious interactome representing critical interaction steps required during the viral lifecycle.
• Curated interactomics for modeling: Provides a curated collection of interactomics data to enable system-level computational modeling of herpesviruses.
• Therapeutic insight: Highlights conserved features that can inform broad-spectrum antiherpetic infection strategies.

Scientific Applications:

• Comparative interactomics: Elucidating evolutionary conserved interactions and protein complexes across the Herpesviridae family.
• Systems-level modeling: Enabling system-level computational modeling of herpesvirus biology using curated interactomics data.
• Therapeutic target identification: Informing identification of conserved targets for broad-spectrum antiherpetic strategies.
• Cross-species applicability: Supporting the concept of a minimal infectious interactome applicable across different hosts.

Methodology:

Integration of experimentally supported and computationally predicted PPIs across representative species followed by comparative analysis to identify family-wise conserved interactions that form the central intraviral protein interactome.