HisgAtlas

HisgAtlas catalogs human immunosuppression genes and their disease associations to provide a literature-derived resource for studying immune regulation and identifying therapeutic biomarkers.

Key Features:

• Extensive Gene Collection: Contains 995 human immunosuppression genes identified through literature mining and manual curation.
• Disease Associations: Links the curated genes to 260 associated human diseases.
• Literature-derived Curation: Gene and disease entries were compiled using text mining and manual curation to integrate published evidence.
• Curated Gene–Disease Associations: Provides curated mappings between immunosuppression genes and diseases to support hypothesis generation.

Scientific Applications:

• Mechanistic Studies: Support investigation of molecular mechanisms underlying immune suppression in human diseases.
• Biomarker and Target Discovery: Facilitate identification of candidate biomarkers and therapeutic targets for immunotherapy and related interventions.
• Disease Association Analysis: Enable cross-disease analyses linking immunosuppression genes to pathological conditions.

Methodology:

Gene and disease entries were obtained through text mining of the literature followed by manual curation.