Hyppo-X
Hyppo-X performs unsupervised structure discovery on high-dimensional phenomics data to reveal higher-order relationships among genotype, phenotype, and environmental variables using algebraic topology and graph theory.
Key Features:
- Unsupervised Structure Discovery: Hyppo-X identifies higher-order structures and latent relationships in phenomics datasets without predefined labels.
- Environmental Influence Analysis: It delineates how environmental factors influence phenotypic traits across genotypes and temporal scales.
- Scalability and Flexibility: Implemented as a header-only library, it scales to large phenomics datasets and supports category definitions using single or multiple dataset columns.
Scientific Applications:
- Maize phenomics analysis: Applied to real-world maize datasets to characterize environmental impacts on phenotypic traits.
- Hypothesis extraction: Formalizes systematic hypothesis generation and extraction from complex phenomics data.
Methodology:
Hyppo-X applies unsupervised learning grounded in algebraic topology and graph theory to uncover higher-order structures in phenomics data.
Topics
Details
- Tool Type:
- library
- Added:
- 1/9/2020
- Last Updated:
- 12/11/2020
Operations
Publications
Kamruzzaman M, Kalyanaraman A, Krishnamoorthy B, Hey S, Schnable PS. Hyppo-X: A Scalable Exploratory Framework for Analyzing Complex Phenomics Data. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2021;18(4):1535-1548. doi:10.1109/tcbb.2019.2947500. PMID:31647442.
PMID: 31647442
Funding: - National Science Foundation: 1661348, 1819229