Hyppo-X

Hyppo-X performs unsupervised structure discovery on high-dimensional phenomics data to reveal higher-order relationships among genotype, phenotype, and environmental variables using algebraic topology and graph theory.


Key Features:

  • Unsupervised Structure Discovery: Hyppo-X identifies higher-order structures and latent relationships in phenomics datasets without predefined labels.
  • Environmental Influence Analysis: It delineates how environmental factors influence phenotypic traits across genotypes and temporal scales.
  • Scalability and Flexibility: Implemented as a header-only library, it scales to large phenomics datasets and supports category definitions using single or multiple dataset columns.

Scientific Applications:

  • Maize phenomics analysis: Applied to real-world maize datasets to characterize environmental impacts on phenotypic traits.
  • Hypothesis extraction: Formalizes systematic hypothesis generation and extraction from complex phenomics data.

Methodology:

Hyppo-X applies unsupervised learning grounded in algebraic topology and graph theory to uncover higher-order structures in phenomics data.

Topics

Details

Tool Type:
library
Added:
1/9/2020
Last Updated:
12/11/2020

Operations

Publications

Kamruzzaman M, Kalyanaraman A, Krishnamoorthy B, Hey S, Schnable PS. Hyppo-X: A Scalable Exploratory Framework for Analyzing Complex Phenomics Data. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2021;18(4):1535-1548. doi:10.1109/tcbb.2019.2947500. PMID:31647442.

PMID: 31647442
Funding: - National Science Foundation: 1661348, 1819229