IA-Lab

IA-Lab provides MATLAB-based computational tools for high-throughput microscopy image analysis, enabling segmentation, measurement, and quantification of multidimensional and multichannel microscopy data.


Key Features:

  • MATLAB implementation: Core functionality and workflows are implemented in MATLAB.
  • Modular design: An object-oriented architecture enables customization and extension by replacing or adding components.
  • Pre-defined analysis workflows: Includes workflows that parse multidimensional and multichannel images into analyzable formats.
  • Segmentation: Provides tools for segmenting complex microscopy image data to isolate regions of interest.
  • Measurement and quantification: Enables precise measurement and quantification of features within segmented images.
  • Result export and visualization: Supports exporting results in multiple formats and displaying raw and processed images.

Scientific Applications:

  • Intracellular transport quantification: Applied to quantify intracellular transport of internalized peptide-drug conjugates.
  • Custom microscopy analyses: Supports development of tailored image-analysis solutions for unique microscopy experimental needs.

Methodology:

Object-oriented MATLAB architecture that enables integration of new analysis components with minimal code modification.

Topics

Details

License:
LGPL-3.0
Tool Type:
command-line tool
Programming Languages:
MATLAB
Added:
11/14/2019
Last Updated:
12/11/2020

Operations

Publications

Corrigan AM, Karlsson J, Wildenhain J, Knerr L, Ölwegård-Halvarsson M, Karlsson M, Lünse S, Wang Y. IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate. PLOS ONE. 2019;14(8):e0220627. doi:10.1371/journal.pone.0220627. PMID:31369634. PMCID:PMC6675096.