IRNdb

IRNdb catalogs immunologically relevant non-coding RNA interactions, annotations, and pathway information to support study of ncRNA regulation in the mouse immune system.

Key Features:

• Comprehensive integration: IRNdb consolidates predicted and experimentally supported ncRNA-target interactions for microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and PIWI-interacting RNAs (piRNAs) linked to immune-related targets.
• Interaction counts: The database documents 12,930 miRNA–target interactions involving 724 distinct miRNAs and 2,427 mouse immune-related targets, 22,453 lncRNA–immune target interactions, and 377 piRNA–immune target interactions.
• Functional annotations and pathways: IRNdb provides annotations for ncRNAs and their gene targets together with associated biological pathways and processes.
• Mouse-specific dataset: The resource focuses on mouse-specific ncRNA–target interaction data and immune-related targets.
• Standardized formatting: Data are provided with uniform formatting to ensure consistency and reliability across datasets.

Scientific Applications:

• Hypothesis generation: Supports identification of candidate ncRNA–target interactions for downstream experimental validation.
• Experimental planning: Provides interaction and annotation data to inform design of experiments investigating ncRNA roles in immune processes.
• Regulatory network analysis: Facilitates exploration of novel regulatory mechanisms and pathway-level impacts of ncRNAs in immunology.

Methodology:

IRNdb integrates mouse-specific ncRNA–target interaction data by combining computational predictions and empirical evidence and applies uniform formatting across datasets.