ImmuneScape

ImmuneScape performs structural modeling of interactions between T cell receptors (TCRs) and peptide-MHC (pMHC) complexes to predict antigen specificity and analyze TCR–antigen affinity.

Key Features:

• Structural Modeling for Antigen Recognition: Uses structural modeling to predict how TCRs recognize antigens and epitopes through molecular complementarity with pMHC complexes.
• Genome-scale Structure-based Function Prediction: Applies structure-based approaches to predict protein functions and map antigens/epitopes targeted by B and T lymphocyte receptors.
• Integration with BCR and TCR Sequencing Data: Complements B cell receptor (BCR) and TCR sequencing methods to connect sequence-level repertoires with modeled receptor–antigen structures.
• Focus on TCR–pMHC Interactions: Specifically models interactions between T cell receptors and peptide-MHC complexes to address TCR-specific structural questions.

Scientific Applications:

• Antigen Specificity Prediction: Models TCR–pMHC interfaces to infer which antigens and epitopes are recognized by specific TCRs.
• Affinity Analysis: Provides structural insights relevant to assessing relative affinity between TCRs and antigens.
• Structure-Based Function Prediction: Supports structure-informed hypotheses about receptor function that can guide experimental validation.

Methodology:

ImmuneScape employs structural modeling techniques to simulate interactions between TCRs and peptide-MHC (pMHC) complexes based on the principle of molecular complementarity.