KRAB ZNF explorer

KRAB ZNF explorer analyzes mRNA expression profiles of Krüppel-associated box domain zinc finger proteins (KRAB-ZNFs) across The Cancer Genome Atlas (TCGA) tissues and cancer types to support comparative, epigenetic, and isoform-level investigations.

Key Features:

• TCGA mRNA integration: Integrates mRNA expression data from The Cancer Genome Atlas (TCGA) across multiple tissues and cancer types.
• Comparative Expression Analysis: Compares KRAB-ZNF expression levels between normal and cancerous tissues.
• Pathological Feature Association: Assesses associations between KRAB-ZNF expression and pathological features, including survival outcomes.
• DNA Methylation Correlation: Correlates KRAB-ZNF expression with global DNA methylation status.
• Isoform Expression Analysis: Analyzes isoform-level expression of KRAB-ZNFs.
• Normal Tissue Expression Levels: Provides baseline analyses of KRAB-ZNF expression in normal tissues.

Scientific Applications:

• Cancer mechanism studies: Investigating molecular underpinnings of cancer involving KRAB-ZNF transcription factors.
• Gene regulation and epigenetics: Studying KRAB-ZNF–mediated gene regulation and epigenetic modifications via DNA methylation correlations.
• Prognostic and therapeutic research: Identifying potential therapeutic targets and assessing prognostic significance of KRAB-ZNF expression, including survival associations.

Methodology:

Analyses explicitly include comparative expression analysis (normal vs cancer), pathological feature association including survival analysis, correlations with DNA methylation, isoform-level expression analysis, and normal tissue expression analyses; the application is implemented as a Shiny application.