LABiocin database

LABiocin catalogs bacteriocins produced by lactic acid bacteria (LAB), providing names, classes, amino acid and nucleic acid sequences, annotations, and analysis resources to support study of their antimicrobial properties.

Key Features:

• Data Compilation: Consolidates names, classes, amino acid sequences and nucleic acid sequences of LAB-derived bacteriocins and stores the dataset in a MySQL database (development using NetBeans IDE).
• Detailed Annotations: Records target microorganisms, origin of bacteriocins, status of producing strains, culture conditions, and methods for extraction and purification.
• Phylogenetic Analysis: Constructs phylogenetic trees based on mature peptide sequences to assess evolutionary relationships among LAB bacteriocins.
• BLAST Homology Search: Provides a BLAST tool for homology searches against mature peptide sequences.
• Cross-Database Linking: Links entries to other databases that provide insights into predicted bacteriocin structures and mechanisms of action.
• Functional Analysis: Supports functional analysis of bacteriocins with relevance to food safety, preservation, and development of antimicrobial therapeutics.

Scientific Applications:

• Food Preservation: Provides antimicrobial activity and related data to support development of natural preservatives for improving food safety and shelf life.
• Antibiotic Alternatives: Facilitates investigation of bacteriocin mechanisms of action as potential alternatives or supplements to traditional antibiotics.
• Drug Development: Supplies sequence and functional information to aid identification of bacteriocins and properties relevant to novel drug candidate development.

Methodology:

Data storage in MySQL; development with NetBeans IDE; construction of phylogenetic trees from mature peptide sequences; BLAST-based homology searches against mature peptide sequences.