LGE

LGE software analyzes fibrotic scarring in non-ischemic dilated cardiomyopathy using late gadolinium-enhanced cardiac magnetic resonance images. The tool constructs 2D electrophysiological simulation models from the MRI scans, assigning microstructures to areas of late gadolinium enhancement to model fibrotic scarring details below the scan resolution. Simulated electrical stimulation tests the models for transmural block or reentry, and the results are compared with morphological features extracted from the images.

The analysis shows that models exhibiting block or reentry differ significantly in myocardial-LGE interface length, number of components, and entropy but not in relative area and transmurality. Transmurality alone best predicts block, while a combination of interface length, transmurality, and number of components best predicts reentry when the microstructure is unknown.