LIBR MOCD

LIBR MOCD provides a validated repository of 360 pictorial cues for methamphetamine- and opioid-related drug cue reactivity (DCR) research, including matched neutral controls and automated selection of equivalent image sets for fMRI studies.

Key Features:

• Comprehensive Image Repository: 360 images divided into methamphetamine, opioid, and neutral categories, matched for objects, hands, faces, and actions.
• Empirical Validation: Images were rated by 28 participants with histories of methamphetamine and opioid use (abstinent >6 months) on craving, valence, arousal, typicality, and relatedness.
• Drug vs Neutral Differentiation: Drug-related images elicited significantly higher arousal and lower valence than neutral images, with craving scores of opioid (87.7±18.5), methamphetamine (88±18), and neutral (11.5±21.9).
• Equivalence Across Drug Types: No significant difference was observed between methamphetamine and opioid images in craving, arousal, or valence.
• Craving–Response Time Relationship: A significant positive correlation was reported between self-reported craving and image viewing/response time, with every 10-point craving increase corresponding to ~383 ms additional response time.
• Automated fMRI Image Set Selection: The database includes three automatically selected image sets matched for equivalence in functional magnetic resonance imaging (fMRI) experiments involving methamphetamine and opioid cues.

Scientific Applications:

• Drug Cue Reactivity Studies: Use validated pictorial cues to quantify psychological responses (craving, valence, arousal) to methamphetamine and opioid stimuli.
• Neuroimaging Experiments: Deploy equivalent image sets in fMRI protocols to assess neural correlates of cue processing for methamphetamine and opioid cues.
• Behavioral and Psychophysiological Assessment: Correlate subjective ratings with response time measures to investigate mechanisms underlying cue-induced craving.
• Intervention and Experimental Control: Provide matched stimulus sets for repeated measures, between-group comparisons, or intervention studies requiring stimulus equivalence.

Methodology:

Images were content-matched (objects, hands, faces, actions), rated by 28 abstinent participants on craving, valence, arousal, typicality, and relatedness; statistical comparisons between image categories and correlation analyses between craving scores and response times were performed, and an automated procedure selected three equivalent image sets for fMRI use.