Legofit

Legofit is a software package that estimates population history parameters using genetic data. It addresses biases and identifiability issues present in other statistical methods by simultaneously estimating parameters related to admixture, ancestral population sizes, and their separation times.

Key features of Legofit include:

1. Data manipulation: It provides tools to process and prepare genetic data for analysis.

2. Parameter estimation: Legofit can simultaneously estimate parameters describing admixture events, population sizes, and the timing of population splits.

3. Residual analysis: The software allows users to examine residuals to assess the model's fit to the data.

4. Model selection and averaging: Legofit incorporates methods for comparing different models and combining results from multiple models, essential for dealing with statistical identifiability issues.

Topic

Population genetics;Mapping;Genetic variation

Detail

  • Operation: Modelling and simulation;Regression analysis

  • Software interface: Command-line interface

  • Language: C

  • License: Internet Systems Consortium License

  • Cost: Free of charge with restrictions

  • Version name: 1.87

  • Credit: NSF and the Center for High Performance Computing at the University of Utah.

  • Input: -

  • Output: -

  • Contact: Alan R. Rogers rogers@anthro.utah.edu

  • Collection: -

  • Maturity: Stable

Publications

  • Legofit: estimating population history from genetic data.
  • Rogers AR. Legofit: estimating population history from genetic data. Legofit: estimating population history from genetic data. 2019; 20:526. doi: 10.1186/s12859-019-3154-1
  • https://doi.org/10.1186/S12859-019-3154-1
  • PMID: 31660852
  • PMC: PMC6819480

Download and documentation


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