LncBook

LncBook curates a high-quality, expert-annotated collection of human long noncoding RNAs (lncRNAs) with integrated multi-omics annotations to support functional characterization and disease association studies.

Key Features:

• Expert curation: Provides an expert-reviewed collection of human lncRNA genes and entries.
• Multi-omics integration: Integrates expression profiles, DNA methylation patterns, and genetic variation data for each lncRNA.
• Functional annotation: Includes curated information on predicted and reported functional roles of lncRNAs.
• Disease associations: Documents associations between lncRNAs and human diseases derived from curated evidence.
• Systematic curation process: Employs a structured, systematic approach to generate comprehensive annotations across omics levels.
• Complementarity: Serves as an expert-driven complement to LncRNAWiki for lncRNA annotation resources.

Scientific Applications:

• lncRNA annotation: Standardizes and enriches annotations for human lncRNA genes to aid genomic studies.
• Functional characterization: Supports investigation of lncRNA functional roles using integrated expression and methylation data.
• Disease association studies: Facilitates discovery and prioritization of lncRNAs implicated in human diseases through curated variation and association data.
• Resource integration and benchmarking: Enables comparison and complementing of community-curated resources such as LncRNAWiki.

Methodology:

Expert-driven systematic curation integrating multi-omics datasets—expression profiles, DNA methylation, genetic variation—and curated functional and disease association information.