LncTarD

LncTarD curates experimentally supported lncRNA–target regulatory relationships, associated functional and expression data, and drug resistance/sensitivity annotations to enable research on long non-coding RNA roles in human diseases.

Key Features:

• Extensive Data Collection: Contains 2,822 key lncRNA–target regulations involving 475 distinct lncRNAs and 1,039 target genes across 177 human diseases, manually curated for experimental support.
• Functional Regulations and Expression Associations: Includes 1,613 experimentally supported functional regulations and 1,209 expression associations linking lncRNAs to biological effects in disease contexts.
• Biological Function Insights: Provides curated information on biological functions driven by disease-related lncRNAs to inform mechanistic interpretation.
• Drug Resistance and Sensitivity Data: Details lncRNA–target regulations implicated in drug resistance or sensitivity, including experimentally supported annotations.
• Comprehensive Cancer Data: Integrates lncRNA microarray data, sequence data, and transcriptome data from a TCGA pan-cancer cohort of 11,373 patients for cross-cancer analyses.

Scientific Applications:

• Biomarker and Therapeutic Target Discovery: Supports identification of novel biomarkers and therapeutic targets by linking lncRNA deregulation to downstream targets and functions.
• Mechanistic Studies of Disease Progression and Drug Response: Enables investigation of molecular mechanisms underlying disease progression and drug response through curated regulatory relationships.
• Pan-Cancer Functional Characterization: Facilitates characterization of lncRNA–target interaction dynamics across cancer types using TCGA microarray, sequence, and transcriptome data from 11,373 patients.

Methodology:

Manual literature curation and integration of experimentally supported lncRNA–target regulations, experimentally validated functional associations, drug resistance–related datasets, and TCGA pan-cancer lncRNA microarray, sequence, and transcriptome data (11,373 patients).