MDCAP

MDCAP (MiRNA-Disease Causal Association Predictor) is a computational tool to predict causal associations between microRNAs (miRNAs) and diseases. The key features and functionalities of MDCAP are:

1. Database integration: MDCAP incorporates manually curated causal miRNA-disease association information from the updated Human miRNA Disease Database (HMDD).

2. Causal association prediction: The tool employs a computational model to predict novel causal miRNA-disease associations beyond merely presenting known associations.

3. Performance evaluation: MDCAP achieved an area under the receiver operating characteristic (ROC) curve of 0.928 for the independent test and 0.925 for 10-fold cross-validation, indicating its high predictive accuracy.

Topic

Functional, regulatory and non-coding RNA;Pathology;Cardiology;Molecular biology;Gene transcripts

Detail

  • Operation: Validation;miRNA target prediction;miRNA expression analysis

  • Software interface: Command-line interface

  • Language: Python

  • License: Not stated

  • Cost: Free of charge

  • Version name: -

  • Credit: National Key R&D Program, Natural Science Foundation of China, Fundamental Research Funds for Central Universities of China.

  • Input: -

  • Output: -

  • Contact: Yuan Zhou zhouyuanbioinfo@hsc.pku.edu.cn, Qinghua Cui cuiqinghua@hsc.pku.edu.cn

  • Collection: -

  • Maturity: -

Publications

  • A Computational Model to Predict the Causal miRNAs for Diseases.
  • Gao Y, et al. A Computational Model to Predict the Causal miRNAs for Diseases. A Computational Model to Predict the Causal miRNAs for Diseases. 2019; 10:935. doi: 10.3389/fgene.2019.00935
  • https://doi.org/10.3389/FGENE.2019.00935
  • PMID: 31632446
  • PMC: PMC6786093

Download and documentation

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