MITK-ModelFit

MITK-ModelFit provides model fitting infrastructure for medical imaging, enabling quantitative parameter estimation from DCE-MRI/CT, diffusion-weighted MRI (ADC and IVIM), and chemical exchange saturation transfer (CEST) Z-spectra.

Key Features:

• Architecture abstraction: Abstracts local models, fitting infrastructure, and results representation to decouple model definition from fitting execution.
• Custom model and algorithm support: Supports development and integration of custom models and fitting algorithms.
• Libraries and plug-ins: Includes ready-to-use libraries and plug-ins with components for DCE-MRI analysis, fit evaluation, and visualization.
• MITK integration and data handling: Integrates with the Medical Imaging Interaction Toolkit (MITK) for data loading, pre-processing, and post-processing within analysis workflows.
• Validation with digital phantoms: Validated using existing and novel digital phantoms with quantified deviations between fit results and ground truth.

Scientific Applications:

• Pharmacokinetic modeling: Construction and extension of pharmacokinetic models for DCE-MRI and DCE-CT.
• Diffusion analysis: Calculation of apparent diffusion coefficients (ADC) and intravoxel incoherent motion (IVIM) modeling in diffusion-weighted MRI.
• CEST analysis: Analysis and modeling of Z-spectra in chemical exchange saturation transfer MRI.
• Quantitative parameter estimation: Estimation of quantitative perfusion and diffusion parameters from medical imaging datasets.

Methodology:

Abstraction of model, fitter, and result representations to enable custom model and fitting-algorithm development and integration into MITK workflows, with validation using digital phantoms comparing fit outputs to ground truth.