MOST-visualization

MOST-visualization visualizes genome-scale metabolic networks (GEMs) by mapping reactions, pathways, and metabolites onto an integrated overview to support interpretation of cellular metabolism.

Key Features:

• Automation: Automates visualization of large genome-scale metabolic networks to reduce manual map generation.
• Understandable maps: Produces clear maps that facilitate identification of pathways, reactions, and metabolites within the network.
• Network interconnectivity visualization: Provides integrated views of how different pathways are interconnected across the metabolic network.
• Pre-drawn overview map (Roche map): Leverages a pre-drawn overview map based on the Roche map to provide a consistent layout for interpretation.
• Integration with MOST: Extends and integrates with the Metabolic Optimization and Simulation Tool (MOST) to enable genome-scale mapping.

Scientific Applications:

• Cellular metabolism analysis: Visualizes GEMs to support interpretation and analysis of cellular metabolic states.
• Metabolic pathway optimization: Aids design and assessment of pathway modifications for industrial metabolic engineering.
• Therapeutic target exploration: Supports identification and visualization of potential metabolic therapeutic targets at genome scale.

Methodology:

Extends the MOST software package and integrates it with a pre-drawn overview map based on the Roche map to automate mapping of GEM reactions, pathways, and metabolites.