MS-Helios

MS-Helios generates circular proteome maps (CPMs) and other Circos-based circular plots from proteomics, metabolomics, and post-translational modification data derived from high-resolution mass spectrometry to visualize and integrate multi-omic datasets.

Key Features:

• Construction of CPMs and circular plots: Produces circular proteome maps (CPMs) and other circular visualizations based on Circos file formats.
• Built-in data processing functions: Transforms raw proteomics, metabolomics, and post-translational modification data into visualization-ready data structures.
• Automatic file generation: Generates data and Circos configuration files required to render circular plots.
• Dimensionality reduction and compact representation: Reduces dimensionality to represent complex, high-resolution mass spectrometry datasets compactly for holistic visualization.
• Multi-omic integration: Maps and visualizes integrated datasets across proteomics, metabolomics, and PTMs to reveal global trends and contextualize specific features.

Scientific Applications:

• High-resolution mass spectrometry visualization: Visualizes complex datasets derived from high-resolution MS to display proteins, metabolites, and post-translational modifications.
• Large-scale multi-omic studies: Identifies global trends and relationships across integrated multi-omic datasets.
• Feature contextualization: Places specific proteins, metabolites, or modifications in the context of broader proteome- and metabolome-scale patterns.

Methodology:

Transforms raw proteomics and metabolomics data into formats compatible with Circos-based circular plots, applies dimensionality reduction for compact representation, and automatically generates the corresponding data and Circos configuration files.