MSDB

MSDB catalogs and annotates microsatellites (short tandem repeats of 1-6 nucleotide motifs) across 37,680 genomes, comprising over 4 billion microsatellites, to support studies of genome organization, gene regulation, evolutionary dynamics, and disease-associated length polymorphisms.

Key Features:

• Comprehensive Coverage: Contains over 4 billion microsatellites derived from 37,680 genomes across diverse species.
• Annotated Collection: Provides an extensively annotated repository of microsatellites.
• Modular Architecture: Employs a modular system that supports regular updates and continuous integration of new genomic data.
• Curated Data: Records are meticulously curated to ensure accuracy and relevance.

Scientific Applications:

• Genome Organization: Enables analysis of microsatellite distribution and abundance to inform studies of genome structure.
• Gene Regulation: Supports investigation of microsatellites' roles in regulatory functions.
• Evolutionary Biology and Comparative Genomics: Facilitates comparative analyses to identify taxon-specific patterns and evolutionary trends across species.
• Molecular Epidemiology: Provides data applicable to studies of microsatellite variation in bacterial pathogens and other microbial organisms.
• Disease Association Studies: Supports examination of length polymorphisms in coding regions linked to neurodegenerative disorders.

Methodology:

The database comprises a meticulously curated, annotated collection of microsatellites with a modular architecture enabling continuous integration of new genomic data.