Mabellini

Mabellini provides three-dimensional structural models and annotations of the Mycobacterium abscessus proteome to support structural analysis and antimicrobial target identification.

Key Features:

• Extensive Structural Models: Contains over 13,000 three-dimensional models covering 3,394 Mycobacterium abscessus proteins.
• Domain-based Modelling Methodology: Generates models using a domain-based methodology that leverages up-to-date computational tools.
• Thorough Annotation: Each model is annotated with data sourced from UniProt, CATH, and SCOP, among others.
• Models for Proteins Lacking Experimental Structures: Provides structural models specifically for proteins where experimental structures are unavailable.

Scientific Applications:

• Antimicrobial Target Evaluation: Supports evaluation of prospective antimicrobial targets in Mycobacterium abscessus for drug discovery efforts.
• Structure-Guided Drug Design: Enables structure-based design and assessment of new molecules targeting M. abscessus proteins.
• Structural Biology and Comparative Analysis: Facilitates structural analysis and comparisons across the M. abscessus proteome, including studies relevant to multidrug resistance and infections in immunocompromised individuals such as people with cystic fibrosis.

Methodology:

Three-dimensional models were generated using a domain-based modelling methodology with up-to-date computational tools and annotated using UniProt, CATH, and SCOP.