Mat_Peptide

Mat_Peptide annotates and analyzes mature peptides derived from polyproteins of Caliciviridae, Coronaviridae, Flaviviridae, Picornaviridae, and Togaviridae to provide comprehensive, reference-projected mature peptide sequence annotations for virological research.

Key Features:

• In Silico Proteolytic Processing: Performs post-translational proteolytic processing of polyproteins computationally to generate mature peptides across over 200 species within the specified virus families.
• Pairwise/Global Alignment Annotation: Utilizes pairwise global alignment with reference sequences to project and annotate mature peptide boundaries on query polyproteins.
• Extensive Annotated Sequence Collection: Has generated 156,216 annotated mature peptide sequences derived from the targeted virus families.

Scientific Applications:

• Viral Pathogenesis Studies: Enables analysis of mature peptide sequences to investigate roles in viral life cycles and pathogenicity.
• Drug Discovery and Vaccine Development: Provides annotated mature peptide targets that can inform identification of antiviral drug and vaccine candidates.
• Comparative Virology: Supports comparative analyses of mature peptides across virus families to study viral evolution and diversity.

Methodology:

Reference mature peptide annotations are projected onto query polyprotein sequences via global pairwise alignment, followed by in silico post-translational proteolytic processing to produce mature peptide annotations.