MolArt

MolArt visualizes sequence annotations mapped onto experimental or predicted protein structures to enable exploration of sequence–structure relationships.

Key Features:

• UniProt-based retrieval: Accepts a UniProt ID and downloads relevant sequence annotations, sequence-structure mappings, and structural data.
• Sequence-structure mapping: Maps sequence annotations to corresponding positions in experimental or predicted protein structures.
• Annotation overlay and color-coding: Overlays sequence annotations onto mapped structures with color coding to link sequence and structure views.
• Support for experimental and predicted structures: Handles both experimentally determined and predicted protein structures.
• Integrated display of annotations and structural data: Presents sequence annotations alongside their sequence-structure mappings and pertinent structural data.

Scientific Applications:

• Structural biology: Enables analysis of how sequence annotations relate to protein conformations.
• Bioinformatics: Facilitates integration of sequence annotation data with structural information.
• Computational chemistry: Aids interpretation of the spatial arrangement of amino acid residues relevant to chemical interactions.
• Protein function and interaction analysis: Supports study of residue-level features affecting function and interactions.
• Evolutionary analysis: Assists examination of conservation and variation in sequence context on structures.

Methodology:

Accepts a UniProt ID, downloads sequence annotations along with corresponding sequence-structure mappings and structural data, maps annotations onto experimental or predicted structures, and overlays them with color coding to link sequence and structure views.