N-GlycositeAtlas

N-GlycositeAtlas provides a comprehensive database of human N-linked glycoproteins and mapped N-glycosylation sites to support mass spectrometry-based glycoproteomic analysis.

Key Features:

• Extensive Data Collection: Compiles over 30,000 glycosite-containing peptides representing more than 14,000 N-glycosylation sites from more than 7,200 distinct N-glycoproteins, aggregated from over 100 publications and unpublished laboratory datasets.
• Comprehensive Coverage: Includes data from human-derived tissues, body fluids, and cell lines to enable distribution analyses across cells, tissues, and body fluids.
• Sub-database Organization: Organized into 22 sub-databases each associated with individual tissues or body fluids to support targeted and comparative studies.
• Mass Spectrometry-based Mapping: Indexes glycosite-containing peptides identified as de-glycosylated forms by mass spectrometry to enable precise mapping of N-linked glycosylation sites.

Scientific Applications:

• Glycoproteomic Research: Supports large-scale characterization of N-linked glycoproteins across diverse human sample types.
• Comparative Analysis: Enables comparative distribution analyses of glycoproteins across tissues, body fluids, and cell lines.
• Clinical Studies: Supports investigations of N-glycosylation in health and disease, including biomarker discovery.

Methodology:

Collected human glycosite-containing peptides identified as de-glycosylated forms by mass spectrometry from over 100 publications and unpublished laboratory datasets.