NPInter v4.0

NPInter v4.0 provides a curated database of experimentally validated interactions between noncoding RNAs (ncRNAs) and other biomolecules to support studies of ncRNA-mediated regulation and disease associations.

Key Features:

• Comprehensive Interaction Data: Integrates over 600,000 newly identified experimentally validated ncRNA interactions from high-throughput interactome studies.
• ncRNA–DNA Interactions: Includes ncRNA–DNA interactions derived from ChIRP-seq data to document genomic-level regulation by ncRNAs.
• Circular RNA Interactions: Incorporates interactions involving circular RNAs to expand coverage of ncRNA regulatory mechanisms.
• Disease Association Annotations: Annotates interacting molecules with disease associations to enable investigation of ncRNA links to disease.
• Additional Functional Modules: Provides modules for data analysis and visualization to support downstream computational analyses.

Scientific Applications:

• Functional Genomics: Enables investigation of ncRNA roles in gene regulation and expression through curated interaction data.
• Disease Mechanism Exploration: Supports exploration of how ncRNA interactions contribute to pathogenesis via annotated disease associations.
• Drug Discovery: Facilitates identification of ncRNA-associated targets linked to diseases for therapeutic research.

Methodology:

Data are curated from experimentally validated interactions and high-throughput interactome studies, including ChIRP-seq-derived ncRNA–DNA interactions.